Hydroxyproline-based DNA mimics provide an efficient gene silencing in vitro and in vivo

To be effective, antisense molecules should be stable in biological fluids, non-toxic, form stable and specific duplexes with target RNAs and readily penetrate through cell membranes without non-specific effects on cell function. We report herein that negatively charged DNA mimics representing chira...

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Detalles Bibliográficos
Autores principales: Efimov, Vladimir A., Birikh, Klara R., Staroverov, Dmitri B., Lukyanov, Sergei A., Tereshina, Maria B., Zaraisky, Andrey G., Chakhmakhcheva, Oksana G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456331/
https://www.ncbi.nlm.nih.gov/pubmed/16670431
http://dx.doi.org/10.1093/nar/gkl249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456331/
https://www.ncbi.nlm.nih.gov/pubmed/16670431
http://dx.doi.org/10.1093/nar/gkl249

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