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Hydroxyproline-based DNA mimics provide an efficient gene silencing in vitro and in vivo
To be effective, antisense molecules should be stable in biological fluids, non-toxic, form stable and specific duplexes with target RNAs and readily penetrate through cell membranes without non-specific effects on cell function. We report herein that negatively charged DNA mimics representing chira...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456331/ https://www.ncbi.nlm.nih.gov/pubmed/16670431 http://dx.doi.org/10.1093/nar/gkl249 |