Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell

The kissing-loop complex that initiates dimerization of genomic RNA is crucial for Human Immunodeficiency Virus Type 1 (HIV-1) replication. We showed that owing to its strong similitude with the bacterial ribosomal A site it can be targeted by aminoglycosides. Here, we present its crystal structure...

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Detalles Bibliográficos
Autores principales: Ennifar, Eric, Paillart, Jean-Christophe, Bodlenner, Anne, Walter, Philippe, Weibel, Jean-Marc, Aubertin, Anne-Marie, Pale, Patrick, Dumas, Philippe, Marquet, Roland
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458285/
https://www.ncbi.nlm.nih.gov/pubmed/16679451
http://dx.doi.org/10.1093/nar/gkl317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458285/
https://www.ncbi.nlm.nih.gov/pubmed/16679451
http://dx.doi.org/10.1093/nar/gkl317

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