Characterization of long RNA-cleaving deoxyribozymes with short catalytic cores: the effect of excess sequence elements on the outcome of in vitro selection

We previously conducted an in vitro selection experiment for RNA-cleaving deoxyribozymes, using a combinatorial DNA library containing 80 random nucleotides. Ultimately, 110 different sequence classes were isolated, but the vast majority contained a short14–15 nt catalytic DNA motif commonly known a...

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Detalles Bibliográficos
Autores principales: Schlosser, Kenny, Lam, Jeffrey C.F., Li, Yingfu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458524/
https://www.ncbi.nlm.nih.gov/pubmed/16682452
http://dx.doi.org/10.1093/nar/gkl276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458524/
https://www.ncbi.nlm.nih.gov/pubmed/16682452
http://dx.doi.org/10.1093/nar/gkl276

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