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Human Ape2 protein has a 3′–5′ exonuclease activity that acts preferentially on mismatched base pairs
DNA damage, such as abasic sites and DNA strand breaks with 3′-phosphate and 3′-phosphoglycolate termini present cytotoxic and mutagenic threats to the cell. Class II AP endonucleases play a major role in the repair of abasic sites as well as of 3′-modified termini. Human cells contain two class II...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459411/ https://www.ncbi.nlm.nih.gov/pubmed/16687656 http://dx.doi.org/10.1093/nar/gkl259 |