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G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription

In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine–polypyrimidine element (NHPPE) that is essential for transcription. An interesting feature of the polypurine G-rich strand of NHPPE is its ability to assume an unusual DNA structure that, according to cir...

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Detalles Bibliográficos
Autores principales: Cogoi, Susanna, Xodo, Luigi E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459413/
https://www.ncbi.nlm.nih.gov/pubmed/16687659
http://dx.doi.org/10.1093/nar/gkl286