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G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine–polypyrimidine element (NHPPE) that is essential for transcription. An interesting feature of the polypurine G-rich strand of NHPPE is its ability to assume an unusual DNA structure that, according to cir...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459413/ https://www.ncbi.nlm.nih.gov/pubmed/16687659 http://dx.doi.org/10.1093/nar/gkl286 |