A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

BACKGROUND: All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated (cas) genes that have been previously implicated in a novel form of DNA repair on the basis of comparative analysis of their prot...

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Detalles Bibliográficos
Autores principales: Makarova, Kira S, Grishin, Nick V, Shabalina, Svetlana A, Wolf, Yuri I, Koonin, Eugene V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462988/
https://www.ncbi.nlm.nih.gov/pubmed/16545108
http://dx.doi.org/10.1186/1745-6150-1-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462988/
https://www.ncbi.nlm.nih.gov/pubmed/16545108
http://dx.doi.org/10.1186/1745-6150-1-7

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