RNA aptamers selected against DNA polymerase β inhibit the polymerase activities of DNA polymerases β and κ

DNA polymerase β (polβ), a member of the X family of DNA polymerases, is the major polymerase in the base excision repair pathway. Using in vitro selection, we obtained RNA aptamers for polβ from a variable pool of 8 × 10(12) individual RNA sequences containing 30 random nucleotides. A total of 60 i...

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Detalles Bibliográficos
Autores principales: Gening, Leonid V., Klincheva, Svetlana A., Reshetnjak, Anastasia, Grollman, Arthur P., Miller, Holly
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463896/
https://www.ncbi.nlm.nih.gov/pubmed/16707660
http://dx.doi.org/10.1093/nar/gkl326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463896/
https://www.ncbi.nlm.nih.gov/pubmed/16707660
http://dx.doi.org/10.1093/nar/gkl326

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