Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.

Individuals are exposed to volatile compounds present in tap water by ingestion, inhalation, and dermal absorption. Traditional risk assessments for water often only consider ingestion exposure to toxic chemicals, even though showering has been shown to increase the body burden of certain chemicals...

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Autores principales: Weisel, C P, Jo, W K
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469238/
https://www.ncbi.nlm.nih.gov/pubmed/8834861
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author Weisel, C P
Jo, W K
author_facet Weisel, C P
Jo, W K
author_sort Weisel, C P
collection PubMed
description Individuals are exposed to volatile compounds present in tap water by ingestion, inhalation, and dermal absorption. Traditional risk assessments for water often only consider ingestion exposure to toxic chemicals, even though showering has been shown to increase the body burden of certain chemicals due to inhalation exposure and dermal absorption. We collected and analyzed time-series samples of expired alveolar breath to evaluate changes in concentrations of volatile organic compounds being expired, which reflects the rate of change in the bloodstream due to expiration, metabolism, and absorption into tissues. Analysis of chloroform and trichloethene in expired breath, compounds regulated in water, was also used to determine uptake from tap water by each route (inhalation, ingestion, or absorption). Each route of exposure contributed to the total exposure of these compounds from daily water use. Further, the ingestion dose was completely metabolized before entering the bloodstream, whereas the dose from the other routes was dispersed throughout the body. Thus, differences in potential biologically effective doses depend on route, target organ, and whether the contaminant or metabolite is the biologically active agent.
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spelling pubmed-14692382006-06-01 Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water. Weisel, C P Jo, W K Environ Health Perspect Research Article Individuals are exposed to volatile compounds present in tap water by ingestion, inhalation, and dermal absorption. Traditional risk assessments for water often only consider ingestion exposure to toxic chemicals, even though showering has been shown to increase the body burden of certain chemicals due to inhalation exposure and dermal absorption. We collected and analyzed time-series samples of expired alveolar breath to evaluate changes in concentrations of volatile organic compounds being expired, which reflects the rate of change in the bloodstream due to expiration, metabolism, and absorption into tissues. Analysis of chloroform and trichloethene in expired breath, compounds regulated in water, was also used to determine uptake from tap water by each route (inhalation, ingestion, or absorption). Each route of exposure contributed to the total exposure of these compounds from daily water use. Further, the ingestion dose was completely metabolized before entering the bloodstream, whereas the dose from the other routes was dispersed throughout the body. Thus, differences in potential biologically effective doses depend on route, target organ, and whether the contaminant or metabolite is the biologically active agent. 1996-01 /pmc/articles/PMC1469238/ /pubmed/8834861 Text en
spellingShingle Research Article
Weisel, C P
Jo, W K
Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
title Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
title_full Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
title_fullStr Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
title_full_unstemmed Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
title_short Ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
title_sort ingestion, inhalation, and dermal exposures to chloroform and trichloroethene from tap water.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469238/
https://www.ncbi.nlm.nih.gov/pubmed/8834861
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