Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene.

Chronic exposure of humans to benzene (BZ) causes acute myeloid leukemia (AML). Both BZ and therapy-related secondary AML are characterized by chromosomal translocations that may occur by inappropriate recombinational events. DNA topoisomerase II (topo II) is an essential sulfhydryl (SH)-dependent e...

Descripción completa

Detalles Bibliográficos
Autores principales: Hutt, A M, Kalf, G F
Formato: Texto
Lenguaje:English
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469763/
https://www.ncbi.nlm.nih.gov/pubmed/9118903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469763/
https://www.ncbi.nlm.nih.gov/pubmed/9118903

Ejemplares similares