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Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene.

Chronic exposure of humans to benzene (BZ) causes acute myeloid leukemia (AML). Both BZ and therapy-related secondary AML are characterized by chromosomal translocations that may occur by inappropriate recombinational events. DNA topoisomerase II (topo II) is an essential sulfhydryl (SH)-dependent e...

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Detalles Bibliográficos
Autores principales:	Hutt, A M, Kalf, G F
Formato:	Texto
Lenguaje:	English
Publicado:	1996
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469763/ https://www.ncbi.nlm.nih.gov/pubmed/9118903

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