Crystal engineering of analogous and homologous organic compounds: hydrogen bonding patterns in trimethoprim hydrogen phthalate and trimethoprim hydrogen adipate

BACKGROUND: Trimethoprim [2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine] is an antifolate drug. It selectively inhibits the bacterial dihydrofolate reductase (DHFR) enzyme. RESULTS: In the crystal structures of trimethoprim (TMP)-hydrogen phthalate (1) and trimethoprim-hydrogen...

Descripción completa

Detalles Bibliográficos
Autores principales: Muthiah, Packianathan Thomas, Francis, Savarimuthu, Rychlewska, Urszula, Warżajtis, Beata
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2006
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470456/
https://www.ncbi.nlm.nih.gov/pubmed/16603061
http://dx.doi.org/10.1186/1860-5397-2-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470456/
https://www.ncbi.nlm.nih.gov/pubmed/16603061
http://dx.doi.org/10.1186/1860-5397-2-8

Ejemplares similares