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Why Do Hubs Tend to Be Essential in Protein Networks?
The protein–protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centra...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473040/ https://www.ncbi.nlm.nih.gov/pubmed/16751849 http://dx.doi.org/10.1371/journal.pgen.0020088 |