Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts.

Ethylene dibromide (1,2-dibromoethane, EDB) can be activated to electrophilic species by either oxidative metabolism or conjugation with glutathione. Although conjugation is generally a route of detoxication, in this case it leads to genetic damage. The major DNA adduct has been identified as S-[2-(...

Descripción completa

Detalles Bibliográficos
Autores principales: Guengerich, F P, Peterson, L A, Cmarik, J L, Koga, N, Inskeep, P B
Formato: Texto
Lenguaje:English
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474475/
https://www.ncbi.nlm.nih.gov/pubmed/3329096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474475/
https://www.ncbi.nlm.nih.gov/pubmed/3329096

Ejemplares similares