High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.

Recent investigations on mechanism of carcinogenesis have demonstrated important quantitative relationships between the induction of neoplasia, the molecular dose of promutagenic DNA adducts and their efficiency for causing base-pair mismatch, and the extent of cell proliferation in target organ. Th...

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Detalles Bibliográficos
Autores principales: Swenberg, J A, Richardson, F C, Boucheron, J A, Deal, F H, Belinsky, S A, Charbonneau, M, Short, B G
Formato: Texto
Lenguaje:English
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474488/
https://www.ncbi.nlm.nih.gov/pubmed/3447904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474488/
https://www.ncbi.nlm.nih.gov/pubmed/3447904

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