Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.

By combining the Michaelis-Menten kinetics of metabolism with the two-stage model of Moolgavkar and Knudson (1981) and the extended two-stage model of carcinogenesis proposed by Tan and Gastardo (1985), this paper proceeds to investigate the effects of metabolism of carcinogens on cancer tumor devel...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, W Y, Singh, K P
Formato: Texto
Lenguaje:English
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474501/
https://www.ncbi.nlm.nih.gov/pubmed/3691427
_version_ 1782127924054327296
author Tan, W Y
Singh, K P
author_facet Tan, W Y
Singh, K P
author_sort Tan, W Y
collection PubMed
description By combining the Michaelis-Menten kinetics of metabolism with the two-stage model of Moolgavkar and Knudson (1981) and the extended two-stage model of carcinogenesis proposed by Tan and Gastardo (1985), this paper proceeds to investigate the effects of metabolism of carcinogens on cancer tumor development. It is shown that the nonlinear kinetics of metabolism of carcinogens affect the dose-response relationship mainly through the mutation rates. If the initiator is affected by metabolism, then the metabolism of promoters has very little or negligible effects of the expected incidences and the number of tumors.
format Text
id pubmed-1474501
institution National Center for Biotechnology Information
language English
publishDate 1987
record_format MEDLINE/PubMed
spelling pubmed-14745012006-06-09 Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis. Tan, W Y Singh, K P Environ Health Perspect Research Article By combining the Michaelis-Menten kinetics of metabolism with the two-stage model of Moolgavkar and Knudson (1981) and the extended two-stage model of carcinogenesis proposed by Tan and Gastardo (1985), this paper proceeds to investigate the effects of metabolism of carcinogens on cancer tumor development. It is shown that the nonlinear kinetics of metabolism of carcinogens affect the dose-response relationship mainly through the mutation rates. If the initiator is affected by metabolism, then the metabolism of promoters has very little or negligible effects of the expected incidences and the number of tumors. 1987-10 /pmc/articles/PMC1474501/ /pubmed/3691427 Text en
spellingShingle Research Article
Tan, W Y
Singh, K P
Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
title Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
title_full Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
title_fullStr Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
title_full_unstemmed Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
title_short Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
title_sort assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474501/
https://www.ncbi.nlm.nih.gov/pubmed/3691427
work_keys_str_mv AT tanwy assessingtheeffectsofmetabolismofenvironmentalagentsoncancertumordevelopmentbyatwostagemodelofcarcinogenesis
AT singhkp assessingtheeffectsofmetabolismofenvironmentalagentsoncancertumordevelopmentbyatwostagemodelofcarcinogenesis

Ejemplares similares