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Bioactivation and covalent binding of halothane to liver macromolecules.

In this manuscript we report our attempts to determine if 14C-halothane or its metabolites interact with DNA. Three bioactivation systems were used: in vitro microsomal incubations, isolated hepatocytes, and in vivo administration. Even though we used optimal conditions for bioactivation, no signifi...

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Detalles Bibliográficos
Autores principales: Sipes, I G, Podolsky, T L, Brown, B R
Formato: Texto
Lenguaje:English
Publicado: 1977
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475325/
https://www.ncbi.nlm.nih.gov/pubmed/612442