Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment

BACKGROUND: Studies of model-based linkage analysis show that trait or marker model misspecification leads to decreasing power or increasing Type I error rate. An increase in Type I error rate is seen when marker related parameters (e.g., allele frequencies) are misspecified and ascertainment is thr...

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Detalles Bibliográficos
Autores principales: Mandal, Diptasri M, Sorant, Alexa JM, Atwood, Larry D, Wilson, Alexander F, Bailey-Wilson, Joan E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475629/
https://www.ncbi.nlm.nih.gov/pubmed/16618369
http://dx.doi.org/10.1186/1471-2156-7-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475629/
https://www.ncbi.nlm.nih.gov/pubmed/16618369
http://dx.doi.org/10.1186/1471-2156-7-21

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