Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

BACKGROUND: Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune activation. METHODS: Deglycosylated or intact C-terminal specific high affinity a...

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Detalles Bibliográficos
Autores principales: Carty, Niki C, Wilcock, Donna M, Rosenthal, Arnon, Grimm, Jan, Pons, Jaume, Ronan, Victoria, Gottschall, Paul E, Gordon, Marcia N, Morgan, Dave
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479322/
https://www.ncbi.nlm.nih.gov/pubmed/16686956
http://dx.doi.org/10.1186/1742-2094-3-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479322/
https://www.ncbi.nlm.nih.gov/pubmed/16686956
http://dx.doi.org/10.1186/1742-2094-3-11

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