Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells

BACKGROUND: We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels, cyclin B1-dependent kinase is activated, and...

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Detalles Bibliográficos
Autores principales: Ianzini, Fiorenza, Bertoldo, Alessandro, Kosmacek, Elizabeth A, Phillips, Stacia L, Mackey, Michael A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479380/
https://www.ncbi.nlm.nih.gov/pubmed/16640786
http://dx.doi.org/10.1186/1475-2867-6-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479380/
https://www.ncbi.nlm.nih.gov/pubmed/16640786
http://dx.doi.org/10.1186/1475-2867-6-11

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