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Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells
BACKGROUND: We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels, cyclin B1-dependent kinase is activated, and...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479380/ https://www.ncbi.nlm.nih.gov/pubmed/16640786 http://dx.doi.org/10.1186/1475-2867-6-11 |