Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

BACKGROUND: In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-β signaling is an important sp...

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Detalles Bibliográficos
Autores principales: Valdimarsdottir, Gudrun, Goumans, Marie-José, Itoh, Fumiko, Itoh, Susumu, Heldin, Carl-Henrik, Dijke, Peter ten
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479810/
https://www.ncbi.nlm.nih.gov/pubmed/16571110
http://dx.doi.org/10.1186/1471-2121-7-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479810/
https://www.ncbi.nlm.nih.gov/pubmed/16571110
http://dx.doi.org/10.1186/1471-2121-7-16

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