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Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma

BACKGROUND: Germline mutations in RET are responsible for multiple endocrine neoplasia type 2 (MEN2), an autosomal dominantly inherited cancer syndrome that is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid hyperplasia/adenoma. Recent studies suggest a "se...

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Detalles Bibliográficos
Autores principales: Koch, Christian A, Brouwers, Frederieke M, Vortmeyer, Alexander O, Tannapfel, Andrea, Libutti, Steven K, Zhuang, Zhengping, Pacak, Karel, Neumann, Hartmut PH, Paschke, Ralf
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483898/
https://www.ncbi.nlm.nih.gov/pubmed/16707008
http://dx.doi.org/10.1186/1471-2407-6-131