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CysLT(1 )receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation

BACKGROUND: Cysteine-containing leukotrienes (cysteinyl-LTs) are pivotal inflammatory mediators that play important roles in the pathophysiology of asthma, allergic rhinitis, and other inflammatory conditions. In particular, cysteinyl-LTs exert a variety of effects with relevance to the aetiology of...

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Detalles Bibliográficos
Autores principales: Ravasi, Saula, Citro, Simona, Viviani, Barbara, Capra, Valérie, Rovati, G Enrico
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488842/
https://www.ncbi.nlm.nih.gov/pubmed/16553950
http://dx.doi.org/10.1186/1465-9921-7-42