Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

BACKGROUND: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean f...

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Detalles Bibliográficos
Autores principales: Wilke, Claus O, Lenski, Richard E, Adami, Christoph
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149451/
https://www.ncbi.nlm.nih.gov/pubmed/12590655
http://dx.doi.org/10.1186/1471-2148-3-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149451/
https://www.ncbi.nlm.nih.gov/pubmed/12590655
http://dx.doi.org/10.1186/1471-2148-3-3

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