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Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
BACKGROUND: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean f...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149451/ https://www.ncbi.nlm.nih.gov/pubmed/12590655 http://dx.doi.org/10.1186/1471-2148-3-3 |