Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies

Bulky carcinogen-DNA adducts commonly cause replicative polymerases to stall, leading to a switch to bypass polymerases. We have investigated nucleotide incorporation opposite the major adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the DinB family polymerase, Dpo4, using molecu...

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Detalles Bibliográficos
Autores principales: Zhang, Ling, Rechkoblit, Olga, Wang, Lihua, Patel, Dinshaw J., Shapiro, Robert, Broyde, Suse
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500869/
https://www.ncbi.nlm.nih.gov/pubmed/16820532
http://dx.doi.org/10.1093/nar/gkl425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500869/
https://www.ncbi.nlm.nih.gov/pubmed/16820532
http://dx.doi.org/10.1093/nar/gkl425

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