Information-driven protein–DNA docking using HADDOCK: it is a matter of flexibility

Intrinsic flexibility of DNA has hampered the development of efficient protein−DNA docking methods. In this study we extend HADDOCK (High Ambiguity Driven DOCKing) [C. Dominguez, R. Boelens and A. M. J. J. Bonvin (2003) J. Am. Chem. Soc. 125, 1731–1737] to explicitly deal with DNA flexibility. HADDO...

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Detalles Bibliográficos
Autores principales: van Dijk, Marc, van Dijk, Aalt D. J., Hsu, Victor, Boelens, Rolf, Bonvin, Alexandre M. J. J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500871/
https://www.ncbi.nlm.nih.gov/pubmed/16820531
http://dx.doi.org/10.1093/nar/gkl412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500871/
https://www.ncbi.nlm.nih.gov/pubmed/16820531
http://dx.doi.org/10.1093/nar/gkl412

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