LINE-1 Endonuclease-Dependent Retrotranspositional Events Causing Human Genetic Disease: Mutation Detection Bias and Multiple Mechanisms of Target Gene Disruption

LINE-1 (L1) elements are the most abundant autonomous non-LTR retrotransposons in the human genome. Having recently performed a meta-analysis of L1 endonuclease-mediated retrotranspositional events causing human genetic disease, we have extended this study by focusing on two key issues, namely, muta...

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Detalles Bibliográficos
Autores principales: Chen, Jian-Min, Férec, Claude, Cooper, David N.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510945/
https://www.ncbi.nlm.nih.gov/pubmed/16877817
http://dx.doi.org/10.1155/JBB/2006/56182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510945/
https://www.ncbi.nlm.nih.gov/pubmed/16877817
http://dx.doi.org/10.1155/JBB/2006/56182

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