Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression

Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) α1 or β gene. This perspective summarizes ou...

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Detalles Bibliográficos
Autores principales: O'Shea, Patrick J., Bassett, J.H. Duncan, Cheng, Sheue-yann, Williams, Graham R.
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2006
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513065/
https://www.ncbi.nlm.nih.gov/pubmed/16862217
http://dx.doi.org/10.1621/nrs.04011
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author O'Shea, Patrick J.
Bassett, J.H. Duncan
Cheng, Sheue-yann
Williams, Graham R.
author_facet O'Shea, Patrick J.
Bassett, J.H. Duncan
Cheng, Sheue-yann
Williams, Graham R.
author_sort O'Shea, Patrick J.
collection PubMed
description Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) α1 or β gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.
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spelling pubmed-15130652006-07-20 Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression O'Shea, Patrick J. Bassett, J.H. Duncan Cheng, Sheue-yann Williams, Graham R. Nucl Recept Signal Perspective Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) α1 or β gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues. The Nuclear Receptor Signaling Atlas 2006-07-07 /pmc/articles/PMC1513065/ /pubmed/16862217 http://dx.doi.org/10.1621/nrs.04011 Text en Copyright © 2006, O'Shea et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
O'Shea, Patrick J.
Bassett, J.H. Duncan
Cheng, Sheue-yann
Williams, Graham R.
Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression
title Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression
title_full Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression
title_fullStr Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression
title_full_unstemmed Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression
title_short Characterization of skeletal phenotypes of TRα1(PV) and TRβ(PV) mutant mice: implications for tissue thyroid status and T3 target gene expression
title_sort characterization of skeletal phenotypes of trα1(pv) and trβ(pv) mutant mice: implications for tissue thyroid status and t3 target gene expression
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513065/
https://www.ncbi.nlm.nih.gov/pubmed/16862217
http://dx.doi.org/10.1621/nrs.04011
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