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RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis

BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) is a debilitating disease characterized by exaggerated extracellular matrix deposition and aggressive lung structural remodeling. Disease pathogenesis is driven by fibroblastic foci formation, consequent on growth factor overexpression and myofibroblas...

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Detalles Bibliográficos
Autores principales: Watts, KL, Cottrell, E, Hoban, PR, Spiteri, MA
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513217/
https://www.ncbi.nlm.nih.gov/pubmed/16776827
http://dx.doi.org/10.1186/1465-9921-7-88