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DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis.
DNA lesions that escape repair have a certain probability of giving rise to mutations when the cell divides. Endogenous DNA damage is high: 10(6) oxidative lesions are present per rat cell. An exogenous mutagen produces an increment in lesions over the background rate of endogenous lesions. The effe...
Autores principales: | Ames, B N, Shigenaga, M K, Gold, L S |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519422/ https://www.ncbi.nlm.nih.gov/pubmed/8013423 |
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