Identification of 6-hydroxy-trans,trans-2,4-hexadienoic acid, a novel ring-opened urinary metabolite of benzene.

We studied the in vivo metabolism of benzene in mice to ring-opened compounds excreted in urine. Male CD-1 mice were treated intraperitoneally with benzene (110-440 mg/kg), [14C]benzene (220 mg/kg) or trans, trans-muconaldehyde (MUC; 4 mg/kg), a microsomal, hematotoxic metabolite of benzene. Urine,...

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Detalles Bibliográficos
Autores principales: Kline, S A, Robertson, J F, Grotz, V L, Goldstein, B D, Witz, G
Formato: Texto
Lenguaje:English
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519806/
https://www.ncbi.nlm.nih.gov/pubmed/8275987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519806/
https://www.ncbi.nlm.nih.gov/pubmed/8275987

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