Representation of target-bound drugs by computed conformers: implications for conformational libraries

BACKGROUND: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead compounds can be proposed. The flexibility of ligands is a critical point for the selection of potential drugs. Since comput...

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Detalles Bibliográficos
Autores principales: Günther, Stefan, Senger, Christian, Michalsky, Elke, Goede, Andrean, Preissner, Robert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523373/
https://www.ncbi.nlm.nih.gov/pubmed/16764718
http://dx.doi.org/10.1186/1471-2105-7-293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523373/
https://www.ncbi.nlm.nih.gov/pubmed/16764718
http://dx.doi.org/10.1186/1471-2105-7-293

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