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The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications
Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. Its stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results in activation of intracellular tyrosine kinase, therefore, cell cycle progression. High levels of EGFR expression are co...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524965/ https://www.ncbi.nlm.nih.gov/pubmed/16722544 http://dx.doi.org/10.1186/1748-717X-1-11 |
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author | Zimmermann, Michel Zouhair, Abderrahim Azria, David Ozsahin, Mahmut |
author_facet | Zimmermann, Michel Zouhair, Abderrahim Azria, David Ozsahin, Mahmut |
author_sort | Zimmermann, Michel |
collection | PubMed |
description | Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. Its stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results in activation of intracellular tyrosine kinase, therefore, cell cycle progression. High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of cancers, mostly in squamous-cell carcinoma of the head and neck (SCCHN). Blocking the EGFR by a monoclonal antibody results in inhibition of the stimulation of the receptor, therefore, in inhibition of cell proliferation, enhanced apoptosis, and reduced angiogenesis, invasiveness and metastases. The EGFR is a prime target for new anticancer therapy in SCCHN, and other agents in development include small molecular tyrosine kinase inhibitors and antisense therapies. |
format | Text |
id | pubmed-1524965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-15249652006-08-01 The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications Zimmermann, Michel Zouhair, Abderrahim Azria, David Ozsahin, Mahmut Radiat Oncol Review Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. Its stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results in activation of intracellular tyrosine kinase, therefore, cell cycle progression. High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of cancers, mostly in squamous-cell carcinoma of the head and neck (SCCHN). Blocking the EGFR by a monoclonal antibody results in inhibition of the stimulation of the receptor, therefore, in inhibition of cell proliferation, enhanced apoptosis, and reduced angiogenesis, invasiveness and metastases. The EGFR is a prime target for new anticancer therapy in SCCHN, and other agents in development include small molecular tyrosine kinase inhibitors and antisense therapies. BioMed Central 2006-05-02 /pmc/articles/PMC1524965/ /pubmed/16722544 http://dx.doi.org/10.1186/1748-717X-1-11 Text en Copyright © 2006 Zimmermann et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Zimmermann, Michel Zouhair, Abderrahim Azria, David Ozsahin, Mahmut The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications |
title | The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications |
title_full | The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications |
title_fullStr | The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications |
title_full_unstemmed | The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications |
title_short | The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications |
title_sort | epidermal growth factor receptor (egfr) in head and neck cancer: its role and treatment implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524965/ https://www.ncbi.nlm.nih.gov/pubmed/16722544 http://dx.doi.org/10.1186/1748-717X-1-11 |
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