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PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?

Recent studies demonstrated that PARP-1 [poly(ADP-ribose) polymerase-1] inhibitors kill breast cancer associated gene-1 and –2 (BRCA1/2) deficient cells with extremely high efficiency while BRCA+/- and BRCA+/+ cells are relatively non-responsive to the treatment. It was therefore proposed that PARP-...

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Detalles Bibliográficos
Autores principales: De Soto, Joseph A., Deng, Chu-Xia
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525219/
https://www.ncbi.nlm.nih.gov/pubmed/16906222