Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells

BACKGROUND: Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS: Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Ippolito, Gregory C, Wall, Jason K, Niu, Teresa, Probst, Loren, Lee, Baeck-Seung, Pulford, Karen, Banham, Alison H, Stockwin, Luke, Shaffer, Arthur L, Staudt, Louis M, Das, Chhaya, Dyer, Martin JS, Tucker, Philip W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526750/
https://www.ncbi.nlm.nih.gov/pubmed/16704730
http://dx.doi.org/10.1186/1476-4598-5-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526750/
https://www.ncbi.nlm.nih.gov/pubmed/16704730
http://dx.doi.org/10.1186/1476-4598-5-18

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