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Interfering with TGFβ-induced Smad3 nuclear accumulation differentially affects TGFβ-dependent gene expression

BACKGROUND: Transforming growth factor-β (TGFβ) plays an important role in late-stage carcinogenesis by stimulating invasive behavior of cancer cells, promoting neo-angiogenesis and by helping cancer cells to escape surveillance by the immune system. It also supports colonization of the bone by meta...

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Detalles Bibliográficos
Autores principales: Lindemann, Ralph K, Nordheim, Alfred, Dittmer, Jürgen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153548/
https://www.ncbi.nlm.nih.gov/pubmed/12747808
http://dx.doi.org/10.1186/1476-4598-2-20