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ReadOut: structure-based calculation of direct and indirect readout energies and specificities for protein–DNA recognition

Protein–DNA interactions play a central role in regulatory processes at the genetic level. DNA-binding proteins recognize their targets by direct base–amino acid interactions and indirect conformational energy contribution from DNA deformations and elasticity. Knowledge-based approach based on the s...

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Detalles Bibliográficos
Autores principales: Ahmad, Shandar, Kono, Hidetoshi, Araúzo-Bravo, Marcos J., Sarai, Akinori
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538882/
https://www.ncbi.nlm.nih.gov/pubmed/16844974
http://dx.doi.org/10.1093/nar/gkl104