Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells

BACKGROUND: Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell proliferation and detachment) are produced at a significantly higher rate in tum...

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Detalles Bibliográficos
Autores principales: Wiebe, John P, Lewis, Michael J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154104/
https://www.ncbi.nlm.nih.gov/pubmed/12659654
http://dx.doi.org/10.1186/1471-2407-3-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC154104/
https://www.ncbi.nlm.nih.gov/pubmed/12659654
http://dx.doi.org/10.1186/1471-2407-3-9

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