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Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy
BACKGROUND: Prions as causative agents of transmissible spongiform encephalopathies (TSEs) in humans and animals are composed of the infectious isomer, PrP(Sc), of the cellular prion protein, PrP(C). The conversion and thus the propensity of PrP(C )to adopt alternative folds leads to the species-spe...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557509/ https://www.ncbi.nlm.nih.gov/pubmed/16846506 http://dx.doi.org/10.1186/1472-6807-6-16 |