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Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy

BACKGROUND: Prions as causative agents of transmissible spongiform encephalopathies (TSEs) in humans and animals are composed of the infectious isomer, PrP(Sc), of the cellular prion protein, PrP(C). The conversion and thus the propensity of PrP(C )to adopt alternative folds leads to the species-spe...

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Detalles Bibliográficos
Autores principales:	Kachel, Norman, Kremer, Werner, Zahn, Ralph, Kalbitzer, Hans Robert
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557509/ https://www.ncbi.nlm.nih.gov/pubmed/16846506 http://dx.doi.org/10.1186/1472-6807-6-16

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