Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells

INTRODUCTION: Activation of the type I insulin-like growth factor receptor (IGFIR) promotes proliferation and inhibits apoptosis in a variety of cell types. Transgenic mice expressing a constitutively active IGFIR or IGF-I develop mammary tumors and increased levels of IGFIR have been detected in pr...

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Detalles Bibliográficos
Autores principales: Yanochko, Gina M, Eckhart, Walter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557721/
https://www.ncbi.nlm.nih.gov/pubmed/16584539
http://dx.doi.org/10.1186/bcr1392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557721/
https://www.ncbi.nlm.nih.gov/pubmed/16584539
http://dx.doi.org/10.1186/bcr1392

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