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Sequence-dependent enhancement of hydrolytic deamination of cytosines in DNA by the restriction enzyme PspGI
Hydrolytic deamination of cytosines in DNA creates uracil and, if unrepaired, these lesions result in C to T mutations. We have suggested previously that a possible way in which cells may prevent or reduce this chemical reaction is through the binding of proteins to DNA. We use a genetic reversion a...
Autores principales: | Carpenter, Michael, Divvela, Pradeep, Pingoud, Vera, Bujnicki, Janusz, Bhagwat, Ashok S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557792/ https://www.ncbi.nlm.nih.gov/pubmed/16893959 http://dx.doi.org/10.1093/nar/gkl545 |
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