Transcriptional potential of the γ-globin gene is dependent on the CACCC box in a developmental stage-specific manner

To test the role of CACCC box on γ-globin gene activation, the CACCC box was deleted or mutated and γ-gene expression was monitored in transgenic mice. Disruption of the CACCC box had no effect on γ-gene expression in the cells of embryonic erythropoiesis but it strikingly reduced γ-gene expression...

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Detalles Bibliográficos
Autores principales: Li, Qiliang, Fang, Xiangdong, Olave, Ivan, Han, Hemei, Yu, Man, Xiang, Ping, Stamatoyannopoulos, George
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557803/
https://www.ncbi.nlm.nih.gov/pubmed/16914453
http://dx.doi.org/10.1093/nar/gkl474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557803/
https://www.ncbi.nlm.nih.gov/pubmed/16914453
http://dx.doi.org/10.1093/nar/gkl474

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