Cargando…

Transcriptional potential of the γ-globin gene is dependent on the CACCC box in a developmental stage-specific manner

To test the role of CACCC box on γ-globin gene activation, the CACCC box was deleted or mutated and γ-gene expression was monitored in transgenic mice. Disruption of the CACCC box had no effect on γ-gene expression in the cells of embryonic erythropoiesis but it strikingly reduced γ-gene expression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qiliang, Fang, Xiangdong, Olave, Ivan, Han, Hemei, Yu, Man, Xiang, Ping, Stamatoyannopoulos, George
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557803/ https://www.ncbi.nlm.nih.gov/pubmed/16914453 http://dx.doi.org/10.1093/nar/gkl474

Ejemplares similares

PB2235: COMPLETE DELETION OF THE CACCC BOX OF THE HBB GENE PROMOTER: A NEW MECHANISM LEADING TO A SILENT PHENOTYPE OF BETA THALASSEMIA
por: Mondesert, E., et al.
Publicado: (2022)

NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene
por: Zhu, Xingguo, et al.
Publicado: (2012)

Physiological and Aberrant γ-Globin Transcription During Development
por: Barbarani, Gloria, et al.
Publicado: (2021)

The role of transcriptional activator GATA-1 at human β-globin HS2
por: Cho, Youngran, et al.
Publicado: (2008)

Transcription factor competition at the γ-globin promoters controls hemoglobin switching
por: Liu, Nan, et al.
Publicado: (2021)

Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites
por: Kim, AeRi, et al.
Publicado: (2007)

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription
por: Yun, Won Ju, et al.
Publicado: (2014)

Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major
por: Sun, Kuo-Ting, et al.
Publicado: (2017)

Eos Negatively Regulates Human γ-globin Gene Transcription during Erythroid Differentiation
por: Yu, Hai-Chuan, et al.
Publicado: (2011)

Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells
por: Stavrou, Eleana F., et al.
Publicado: (2019)

The methyltransferase PRMT1 regulates γ-globin translation
por: Wang, Ying, et al.
Publicado: (2021)

Reactivation of a developmentally silenced embryonic globin gene
por: King, Andrew J., et al.
Publicado: (2021)

Intergenic Transcription, Cell-Cycle and the Developmentally Regulated Epigenetic Profile of the Human Beta-Globin Locus
por: Miles, Joanne, et al.
Publicado: (2007)

The Transcription-Repair Coupling Factor Mfd Prevents and Promotes Mutagenesis in a Context-Dependent Manner
por: Lindsey-Boltz, Laura A., et al.
Publicado: (2021)

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia
por: Mettananda, Sachith, et al.
Publicado: (2019)

Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acids
por: Lonkar, Pallavi, et al.
Publicado: (2009)

Minimal components of the RNA polymerase II transcription apparatus determine the consensus TATA box
por: Bjornsdottir, Gudrun, et al.
Publicado: (2008)

Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation
por: Ruiz, Maria Armila, et al.
Publicado: (2015)

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene
por: Fugazza, Cristina, et al.
Publicado: (2020)

MRNA Transcription, Translation, and Defects in Developmental Cognitive and Behavioral Disorders
por: Smith, Moyra
Publicado: (2020)

Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF
por: Freddie, Cecilie T., et al.
Publicado: (2007)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation
por: Moleirinho, Ana, et al.
Publicado: (2013)

Transmembrane Protein ANTXR1 Regulates γ-Globin Expression by Targeting the Wnt/β-Catenin Signaling Pathway
por: Jin, Tingting, et al.
Publicado: (2022)

Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence
por: Xu, Xiaoxin S, et al.
Publicado: (2009)

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts
por: Vinjamur, Divya S., et al.
Publicado: (2016)

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production
por: Breveglieri, Giulia, et al.
Publicado: (2017)

Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer
por: Amir, Sumaira, et al.
Publicado: (2016)

MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis
por: Azzouzi, Imane, et al.
Publicado: (2011)

PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific α-globin expression
por: Chul Kang, Ho, et al.
Publicado: (2010)

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes
por: Woon Kim, Yea, et al.
Publicado: (2011)

Nucleotide sequence and results of test of adaptive evolution in the α-globin gene of octodontoid rodents
por: Tomasco, I.H., et al.
Publicado: (2017)

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis
por: Vervoort, Stephin J, et al.
Publicado: (2018)

Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans
por: Shriner, Daniel, et al.
Publicado: (2015)

Identification of novel γ-globin inducers among all potential erythroid druggable targets
por: Yu, Lei, et al.
Publicado: (2022)

Expression analysis data of BCL11A and γ-globin genes in KU812 and KG-1 cell lines after CRISPR/Cas9-mediated BCL11A enhancer deletion
por: Khosravi, Mohammad Ali, et al.
Publicado: (2019)

The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence
por: Woods, Susan, et al.
Publicado: (2008)

Sevoflurane represses the migration and invasion of gastric cancer cells by regulating forkhead box protein 3
por: Yong, Fangfang, et al.
Publicado: (2021)

The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution
por: Ebner, Bettina, et al.
Publicado: (2010)

TMEM8 – a non-globin gene entrapped in the globin web
por: Philonenko, Elena S., et al.
Publicado: (2009)

HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner
por: Taminiau, Arnaud, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kj0m38d471grtpijksa5415ivu