A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

Human BRCA2, a breast and ovarian cancer suppressor, binds to the DNA recombinase RAD51 through eight conserved BRC repeats, motifs of ∼30 residues, dispersed across a large region of the protein. BRCA2 is essential for homologous recombination in vivo, but isolated BRC repeat peptides can prevent t...

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Detalles Bibliográficos
Autores principales: Shivji, Mahmud K. K., Davies, Owen R., Savill, Jane M., Bates, Debbie L., Pellegrini, Luca, Venkitaraman, Ashok R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557805/
https://www.ncbi.nlm.nih.gov/pubmed/16914443
http://dx.doi.org/10.1093/nar/gkl505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557805/
https://www.ncbi.nlm.nih.gov/pubmed/16914443
http://dx.doi.org/10.1093/nar/gkl505

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