Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors

BACKGROUND: Expression of c-myc proto-oncogene is inappropriate in a wide range of human tumors, and is a downstream target of Ras/Raf/ERK pathway, which promotes c-Myc stability by enhancing c-Myc expression and activity. The aim of this study was to investigate whether the oncogenic phenotype in t...

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Detalles Bibliográficos
Autores principales: Marampon, Francesco, Ciccarelli, Carmela, Zani, Bianca M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560159/
https://www.ncbi.nlm.nih.gov/pubmed/16899113
http://dx.doi.org/10.1186/1476-4598-5-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560159/
https://www.ncbi.nlm.nih.gov/pubmed/16899113
http://dx.doi.org/10.1186/1476-4598-5-31

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