The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs

The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary...

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Detalles Bibliográficos
Autor principal: Smith, Kendall A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562422/
https://www.ncbi.nlm.nih.gov/pubmed/16907989
http://dx.doi.org/10.1186/1476-9433-5-3
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author Smith, Kendall A
author_facet Smith, Kendall A
author_sort Smith, Kendall A
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description The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary complex. What do we know now that we did not know before this structural information was available, and how do these new data help us to develop new therapies?
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spelling pubmed-15624222006-09-08 The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs Smith, Kendall A Med Immunol Review The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary complex. What do we know now that we did not know before this structural information was available, and how do these new data help us to develop new therapies? BioMed Central 2006-08-14 /pmc/articles/PMC1562422/ /pubmed/16907989 http://dx.doi.org/10.1186/1476-9433-5-3 Text en Copyright © 2006 Smith; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Smith, Kendall A
The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
title The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
title_full The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
title_fullStr The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
title_full_unstemmed The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
title_short The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
title_sort structure of il2 bound to the three chains of the il2 receptor and how signaling occurs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562422/
https://www.ncbi.nlm.nih.gov/pubmed/16907989
http://dx.doi.org/10.1186/1476-9433-5-3
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